Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels*

HIGHLIGHTS

• who: Lijun Tian from the (UNIVERSITY) have published the research: Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels*, in the Journal: (JOURNAL) of April/27,/2012
• what: The authors demonstrate that zDHHC22 and zDHHC23 specifically control palmitoylation of the S0 -S1 loop of BK channels to control surface trafficking.

SUMMARY

To date more than 40 different ion_channel subunits have been reported to be palmitoylated. Because the thioester bond is labile, protein palmitoylation is the only reversible posttranslational lipid modification of proteins, thus providing a potentially . . .

 



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