Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the nod2 mutation p.leu1007fsx1008 with crohn’s disease and active smoking status resulting in ileal stenosis requiring surgery

HIGHLIGHTS

• who: Fabian Schnitzler and colleagues from the International University of Health Sciences, ITALY Switzerland, Institute of Laboratory Medicine and Human Genetics, Singen, Germany have published the Article: Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohnu2019s disease and active smoking status resulting in ileal stenosis requiring surgery, in the Journal: PLOS ONE of 20/02/2020
• what: The authors aimed to define the predictive power of the major NOD2 mutations regarding complicated CD in a large single center cohort. The study demonstrates that the . . .
  

   

  

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