HIGHLIGHTS
- who: Pharmaceuticals from the Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, Warsaw, Poland, Ionis have published the article: Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding, in the Journal: (JOURNAL)
- what: The authors report structural and biochemical studies of interactions between annexin A2 a protein that does not possess any known canonical DNA binding domains and phosphorothioate-modified antisense oligonucleotides. The authors show that a unique mode of hydrophobic interactions between a sulfur atom of the phosphorothioate group and lysine and arginine residues account . . .
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