Rational design and synthesis of new selective cox-2 inhibitors with in vivo pge2-lowering activity by tethering benzenesulfonamide and 1,2,3-triazole pharmacophores to some nsaids

HIGHLIGHTS

• who: Nada H. El-Dershaby and collaborators from the Pharmaceutical Chemistry Department, Faculty of Pharmacy, University have published the Article: Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs, in the Journal: Pharmaceuticals 2022, 15, x FOR PEER REVIEW of /2022/
• what: This study aims at the development of new hybrid molecules possessing potent and selective COX-2 inhibitory activity with reduced side effects.
• how: The collected results showed that the ibuprofen analogue 6b . . .
  

   

  

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