A multifaceted evaluation of microgliosis and differential cellular dysregulation of mammalian target of rapamycin signaling in neuronopathic gaucher disease

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  • who: Dao Pan from the Uppsala University, Sweden Sciences (NIBS), China have published the Article: A multifaceted evaluation of microgliosis and differential cellular dysregulation of mammalian target of rapamycin signaling in neuronopathic Gaucher disease, in the Journal: (JOURNAL)
  • what: The authors develop a convenient and efficient tool to quantify microglia proliferation and activation independently and uncover a ~2-fold increase in microglia of nGD mice. The authors investigate nGD-associated pattern of inflammatory mediators and evaluate in situ the correlation Microglia showed abnormal elevation in both the numbers and activation status in 4L;C* brain . . .

     

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