HIGHLIGHTS
- who: Mary-Kate Hayward from the (UNIVERSITY) have published the Article: Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion, in the Journal: (JOURNAL)
- what: The authors show that mimicking the mechanical stretching of myoepithelial_cells in DCIS duct expansion induces a DCIS myoepithelial_cell phenotype associated with invasive progression. The authors demonstrate expression of myoepithelial_cell integrin u03b26 and periductal fibronectin in DCIS associates with a higher propensity to progress to invasive breast cancer. The authors show that this DCIS myoepithelial_cell phenotype is induced by mechanostimulation in a TGFu03b2-dependent manner. The . . .
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