HIGHLIGHTS
- who: Eda R. Machado from the (UNIVERSITY) have published the research: Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice, in the Journal: (JOURNAL)
- what: Mechanistically, the authors show that the transforming pathway is increased lysosomal exocytosis downstream of reduced neuraminidase 1, exemplified by the redistribution of the lysosomal associated membrane protein 1 at the plasma_membrane of tumor and stromal cells. The authors show that reducing Neu1 expression in the Ptch1+/-/ ETV7TG+/- model changes RMS tumors into a pleomorphic state. To assess the molecular events that might contribute to . . .
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