A mitofusin 2 / hif1  axis sets a maturation checkpoint in regenerating skeletal muscle

HIGHLIGHTS

  • who: sheru from the Children`s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX , USA have published the research work: A Mitofusin 2 / Hif1 uf061 axis sets a maturation checkpoint in regenerating skeletal muscle, in the Journal: (JOURNAL)
  • what: The authors report the existence of a maturation checkpoint during muscle regeneration which pauses myofibers at a neonatal stage. The authors investigate role of mitochondria in impacting regeneration following muscle injury, focusing on the mitochondrial outer membrane protein Mitofusin 2 (Mfn2). Analysis, the authors observed elevated CA3 levels in the severe CNM . . .

     

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