Activation of pkc-aldh2 axis prevents 4-hne-induced pain in mice

HIGHLIGHTS

  • who: Bu00e1rbara B. Martins and collaborators from the Laboratory of Pain and Signaling, Butantan Institute, Su00e3o Paulo, SP, BrazilDepartment of Chemical and Systems Biology, School of Medicine, Stanford University, Stanford, CA , have published the research work: Activation of PKC-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice, in the Journal: Biomolecules 2021, 11, 1798. of 25/Oct/2021
  • what: The study provided evidence that the design of molecules that competitively disrupt a specific protein-protein interaction (kinasechaperone), such as, u03a8u03b5HSP90, is a promising approach to develop more feasible drugs that selectively affect only detrimental . . .

     

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