A class i hdac inhibitor bg45 alleviates cognitive impairment through the camkii/itpka/ca2+ signaling pathway

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  • who: Jingyun Liu et al. from the Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China have published the Article: A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca2+ Signaling Pathway, in the Journal: Pharmaceuticals 2022, 1481 of 10/Dec/2021
  • what: In this work the effect of the histone deacetylase (HDACI) on synapse-related proteins was investigated in primary neurons from APP/PS1 transgenic mice.
  • how: The results showed that can upregulate the expression of synaptotagmin-1 (SYT-1) and neurofilament . . .

     

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