HIGHLIGHTS
- who: Christine Rother from the (UNIVERSITY) have published the research work: Experimental evidence for temporal uncoupling of brain Au03b2 deposition and neurodegenerative sequelae, in the Journal: (JOURNAL) of 10/Oct/2022
- how: To elucidate the dependency of downstream pathologies on Au03b2 the authors analyzed the trajectories of cerebral Au03b2 accumulation Au03b2 seeding activity and neurofilament light chain (NfL) in the CSF (a biomarker of neurodegeneration) in Au03b2precursor protein transgenic mice. The DIA PASEF raw data were analyzed with the software DIANN Version 1.867.
- future: If an immunohistologic/biochemical analysis could be performed . . .
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