Baff blockade attenuates acute graft-versus-host disease directly via the dual regulation of t- and b-cell homeostasis

HIGHLIGHTS

• who: Youngwoo Jeon and collaborators from the University of Pittsburgh, United States have published the research work: BAFF blockade attenuates acute graft-versus-host disease directly via the dual regulation of T- and B-cell homeostasis, in the Journal: (JOURNAL)
• what: In this study, BAFF was shown to increase the proportions of CD4+IL-17+, CD4+IL-6+ Th17, and CD4+IFN-g+ Th1 cells and to reduce the proportion of regulatory T (Treg) cells. Keyword graft-versus-host disease, hematopoietic stem_cell transplantation, B-cell-activating factor (BAFF), belimumab, regulatory T-lymphocytes Frontiers in Immunology . . .
  

   

  

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