HIGHLIGHTS
SUMMARY
Phylostratigraphic or gene age analyses provide abundant supporting evidence: cancer-related genes often emerge in unicellular (UC) ancestors or early metazoan (EM) ancestors; UC genes tend to be upregulated in tumors, while EM genes are often downregulated. Compilation of the gene age dataset and cancer omics datasets To analyze the roles of PSGs in tumors, the authors first compiled a genome-wide gene age dataset spanning the most ancient UC genes to the youngest PSGs. Considering that increased proliferation of neural progenitor or stem_cells drives human cerebral expansion and that cancer cells have been . . .
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