The role of auxiliary domains in modulating chd4 activity suggests mechanistic commonality between enzyme families

HIGHLIGHTS

• who: Yichen Zhong from the (UNIVERSITY) have published the article: The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families, in the Journal: (JOURNAL) of 13/06/2022
• what: The authors demonstrate that these regions regulate CHD4 activity through different mechanisms. The model that the authors proposed, however, focuses exclusively on the ATPase/DNA translocase domain. The authors determine the impact of auxiliary domains on the nucleosome sliding activity of CHD4. The authors demonstrate that an N-terminal intrinsically disordered region (IDR) is essential for full remodelling activity, and that . . .
  

   

  

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