Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

HIGHLIGHTS

  • who: Krishna G. Aragam from the (UNIVERSITY) have published the paper: Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants, in the Journal: (JOURNAL) of 26/04/2021
  • what: At several newly identified associations, such as those nearest ITGA1 and MYO9B, the authors provide complementary lines of in silico evidence to nominate potential causal variants, genes and mechanistic pathways. While experimental evidence is ultimately required to confirm causal mechanisms at all unresolved CAD risk loci, the authors provide a prioritization framework yielding evidence-based candidates that . . .

     

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