Differential role of mlkl in alcohol-associated and non- alcohol-associated fatty liver diseases in mice and humans

HIGHLIGHTS

  • who: Item Type and colleagues from the of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USAKumamoto University have published the paper: Differential role of MLKL in alcohol-associated and non- alcohol-associated fatty liver diseases in mice and humans, in the Journal: (JOURNAL) of May/18,/2020
  • what: The authors show here that differential role for mixed-lineage kinase domain-like protein (MLKL) the downstream effector of RIP3 in murine models of ALD versus NAFL/NASH and that RIP1-RIP3-MLKL can be used as biomarkers to distinguish alcohol-associated hepatitis (AH) from NASH.
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