Splenic red pulp macrophages provide a niche for cml stem cells and induce therapy resistance

HIGHLIGHTS

• who: Elias D. Bu00fchrer from the , involved in myeloid lineage commitment in the spleenLSCs in the spleen exclusively located in the red pulp and were dependent on RPMs. Splenectomy reduced the accumulation of LSCs and prolonged survival of CML mice. Therefore, RPMs in the spleen contribute to disease progression and resistance to TKI therapy in CML by accumulating a large pool of primitive LSCs. MATERIAL AND METHODS Mice C BL/, (BL/6) mice were purchased from Charles River and kept under specific pathogen free conditions. Spi-C loss of function mice [15] were obtained from Prof. Christian . . .
  

   

  

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