HIGHLIGHTS
- who: Gi-Sang Seong et al. from the College of Pharmacy, Ajou University, Suwon, Republic of Korea have published the Article: Determination of Leuprolide-Fatty Acid Conjugate in Rat Plasma Using LC-MS/MS and Its Pharmacokinetics after Subcutaneous Administration in Rats, in the Journal: Molecules 2022, 8716 of 15/04/2021
- what: The authors aimed to develop a bioanalytical LC-MS/MS method for leuprolide and its conjugate.
- how: The results showed that this approach significantly increased the circulation half-life of leuprolide when the drug covalently linked to the polymeric micelles . . .
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