HIGHLIGHTS
SUMMARY
Potential degrons in AURKA have been defined mostly through in_vitro studies, with deletion or mutation of either the "A-box" motif or the putative D-box shown to stabilize AURKA against mitotic degradation in one or more assays in_vitro or in living cells (summarized in Table 1). The proposed degron would therefore be inaccessible to APC/C binding unless ubiquitination of AURKA was preceded by an unfolding step, rendering problematic the designation of this motif as a degron, despite the in_vitro evidence of degron function. Littlepage and amp; Ruderman; Littlepage et al; Castro et . . .
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