HIGHLIGHTS
- who: Roy Zent and colleagues from the DivisionVanderbilt University Medical Center, Nashville, Tennessee, USA have published the paper: Cyclin G1 induces maladaptive proximal tubule cell CDK5 activation, in the Journal: (JOURNAL)
- what: The authors sought to determine the relationship between dedifferentiation and G2/M arrest as well as the contribution of each to kidney fibrosis in CKD by targeting CG1. The authors demonstrate that CDK5 and p35 are expressed in chronically injured PTCs, and the expression is regulated by CG1.
- how: The authors examined the role of CG1 in fibrosis progression in several . . .
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