High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura

HIGHLIGHTS

  • who: Pablo Canales-Herrerias and colleagues from the InstitutUniversity, Paris Est Cru00e9teil, Cru00e9teil, France Diaccurate SA, Paris, France. have published the article: High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura, in the Journal: (JOURNAL)
  • what: This study shows the existence and dissemination of high-affinity autoreactive plasma cells in multiple anatomical compartments of patients with ITP that may cause the failure of current therapies. This work reports anti-CD38 daratumumab off-label use in 3 patients with refractory chronic ITP, a treatment that has been proposed for autoimmune . . .

     

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