Genomic features underlie the co-option of sva transposons as cis-regulatory elements in human pluripotent stem cells

HIGHLIGHTS

• who: Samantha M. Barnada and colleagues from the University, Philadelphia, Pennsylvania, United States have published the research: Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells, in the Journal: (JOURNAL) of June/15,/2022
• what: The authors show that a long DNA motif composed of flanking YY1/2 and OCT4 binding sites is enriched in the co-opted SVAs and that these two transcription factors bind consecutively on the TE sequence. The authors demonstrate that ~750 SVAs are depleted of repressive histone marks (i.e. H3K9me3 . . .
  

   

  

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