Tertiary and quaternary structure organization in gmp synthetases: implications for catalysis

HIGHLIGHTS

  • who: Lionel Ballut and colleagues from the Molecular Microbiology and Structural Biochemistry, CNRS-University of Lyon1, Passage du have published the paper: Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis, in the Journal: Biomolecules 2022, 871 of 11/05/2022
  • what: In this manuscript the authors report on an unusual structural variation in the crystal structure of the C89A/C113A Pf GMPS double mutant wherein a larger degree of domain rotation has led to the dissociation of the dimeric structure. The authors report a hitherto overlooked signature motif tightly related to catalysis . . .

     

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