HIGHLIGHTS
SUMMARY
Frontiers in Endocrinology frontiersin.org 10.3389/fendo.2022.981487 bone loss in age-related osteoporosis is the altered lineage allocation of Bone Marrow Stromal Cells (BMSCs), associated with enhanced differentiation towards adipocyte lineage, leading to expansion of the Bone Marrow Adipose Tissue (BMAT), at the expense of compromised osteoblast differentiation and bone formation. Age-related expansion of BMAT and osteoporotic bone loss are mediated through intrinsic and extrinsic mechanisms, such as cellular senescence within the bone microenvironment or agerelated endocrine dysfunction. Osteoporosis Osteoporosis is a chronic-skeletal disorder characterized by low bone mass . . .
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