Understanding the polyamine and mtor pathway interaction in breast cancer cell growth

HIGHLIGHTS

  • who: Oluwaseun Akinyele and Heather M. Wallace from the Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen , ZD, UK have published the research: Understanding the Polyamine and mTOR Pathway Interaction in Breast Cancer Cell Growth, in the Journal: (JOURNAL)
  • what: The authors investigated the effect of intracellular polyamine modulation on mTORC1 downstream protein and general translation state in two breast cancer cell lines MCF-7 and MDA-MB-231. The use ofofmTOR as a monotherapy hasconsider shown limited clinical success in the treatment of solidand tumors. consider aIncombination . . .

     

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