Distinct cell type-specific protein signatures in grn and mapt genetic subtypes of frontotemporal dementia

HIGHLIGHTS

  • who: Suzanne S. M. Miedema from the Department of Molecular and Cellular Neurobiology, Center HV, The Netherlands have published the article: Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia, in the Journal: (JOURNAL) of April/30,/2009
  • what: The authors demonstrate that comparison of proteomic profiles of different disease entities can separate general neurodegenerative processes from disease-specific pathways which may aid the development of disease subtype-specific treatment strategies.
  • how: For detailed analysis regarding affected synaptic processes the authors used SynGO (version 20180731) with FDR . . .

     

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