Implications of possible hbv-driven regulation of gene expression in stem cell-like subpopulation of huh-7 hepatocellular carcinoma cell line

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    In Huh-7 HCC cell lines, epithelial_cell adhesion molecule (EpCAM)- and Prominin-1 J. Pers. 2022, 12, 2065. https://doi.org/10.3390/jpm12122065 2 of 16 (CD133)-co-expressing cell subpopulations were shown to possess stem_cell-like properties, as they frequently caused tumor development in immunocompromised NOD/SCID mice xenograft models. HBx could play essential roles in HBV-associated HCC by interacting with the STIM1 and Orai1 complexes to maintain SOCE, as well as targeting key microRNAs (miRNAs) in host cells. In viral infections, miRNAs can alter viral_replication processes by regulating the viral . . .

     

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