HIGHLIGHTS
- who: Biljana Blagojevic and colleagues from the Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld, Heidelberg, Germany have published the paper: Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1, in the Journal: Cells 2022, 3863 of /2022/
- what: The authors show that canonical GCN2-ATF4-mediated Sestrin2 induction leads to mTORC1 inhibition only in amino acid auxotroph cells where the amino acid cannot be replenished by metabolic reprogramming. Of note, an early regulation in phosphorylation of p38 and ATF4, observed up to . . .
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