Structures of hiv-1 gp120 antagonists

HIGHLIGHTS

• who: Francesca Curreli and colleagues from the Laboratory of Molecular Modeling and Drug Design, Lindsey FKimball Research Institute, New York Blood Center, New York, NY, USA have published the article: Structures of HIV-1 gp120 Antagonists, in the Journal: (JOURNAL)
• what: As part of the effort to discover drugs that target HIV-1 entry the authors report the and structures of two novel inhibitors in a complex with a gp120 core. The authors evaluated both NBD compounds against two mutant pseudovirus HIV-1HXB2 having amino_acid substitutions, S375Y and S375H, in the gp120 region.
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