HIGHLIGHTS
SUMMARY
The intensity of the tumorostatic response to melatonin is related to the cell-line-specific pattern of melanocyte cell surface and nuclear receptor expressions. A number of studies described the relationship of constant lighting, i.e., deficiency of pineal melatonin, with the development of transplantable melanoma B16; the resistance of melanoma to chemotherapy under constant illumination conditions, as well as the antiproliferative and antimigratory effects of melatonin on melanoma cells are established. At the same time, the authors did not find any studies on ultrastructural peculiarities of transplantable malignant melanoma cells under conditions of . . .
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