Substoichiometric hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of sup35 prion domain

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• who: Sayanta Mahapatra from the (UNIVERSITY) have published the Article: Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain, in the Journal: (JOURNAL) of May/19,/2022
• what: At low substoichiometric concentrations, the authors show Hsp104 exhibits a dual role: it considerably accelerates the formation of prefibrillar species by shortening the lag phase but also prolongs their persistence by introducing unusual kinetic halts and delaying their conversion into mature amyloid fibers. The authors show these Hsp104remodeled, conformationally distinct NM aggregates display an enhanced autocatalytic self-templating ability that . . .
  

   

  

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