Multifaceted functions of sting in human health and disease: from molecular mechanism to targeted strategy

HIGHLIGHTS

  • who: Zili Zhang from the (UNIVERSITY) have published the Article: Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy, in the Journal: (JOURNAL) of 26/07/2022
  • what: In this Review, the objective is to summarize the versatile outputs of STING and elucidate the molecular mechanism of STING activation with reference to its structural data.
  • how: In 2004 retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) were found to be the cytosolic dsRNA sensor2425 and in the following 2005 its downstream . . .

     

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