Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach

HIGHLIGHTS

• who: Tommi Vu00e4likangas from the enriched longitudinal proteomics data of Francisella tularensis subspecies novicida (Fn)Francisella tularensis subspecies tularensis (Ft) is a highly pathogenic Gram-negative bacterial agent responsible for the disease tularemia in humans. Research interest on Ft has peaked during the past decades due to the possible application of the bacterial agent in biological warfare and bioterrorism64. As reliable methods for the genetic manipulation of the highly virulent subspecies Ft have been lacking, the more responsive and avirulent subspecies Fn was used as a proxy in an effort to shed light into the mechanisms of . . .
  

   

  

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