HIGHLIGHTS
- who: Xin Yang from the (UNIVERSITY) have published the Article: Exon junction complex shapes the m6A epitranscriptome, in the Journal: (JOURNAL) of 16/08/2022
- what: The authors propose a model in which EJC-binding at exon-exon boundaries reduces the local accessibility of the mRNA to METTL3 resulting in less m6A modification throughout the CDS region of mRNA. The authors provide additional evidence using reporter gene assays to further support this conclusion. The authors propose that m6A occurs throughout the mRNA during transcription albeit at a relatively low stoichiometry, and that subsequent and locally . . .
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