HIGHLIGHTS
SUMMARY
The authors posit that natural compounds would provide an attractive alternative to synthetic collagenase inhibitors, as some studies indicate that plant-derived oligosaccharides, polyphenols, and fatty_acids bind reversibly to the catalytic zinc. The authors performed an extensive initial screening evaluating the inhibitory activity of 77 compounds on collagenase A. For the most promising derivatives, the authors further determined the corresponding half maximal inhibitory concentration (IC50) and performed molecular modeling to understand the potential interactions between the isolated compounds and the enzyme. The docking search space was established around the peptidase domain, the active_site including . . .
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