Synthesis and preclinical evaluation of small-molecule prostate-specific membrane antigen-targeted abiraterone conjugate

HIGHLIGHTS

  • who: Aleksei E. Machulkin and collaborators from the Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building, GSP-1, Moscow, Russia have published the Article: Synthesis and Preclinical Evaluation of Small-Molecule Prostate-Specific Membrane Antigen-Targeted Abiraterone Conjugate, in the Journal: Molecules 2022, 8795 of /2022/
  • what: The authors performed the synthesis of a novel small-molecule based on Cytotoxicity the induction of intracellular reactive oxygen species and P450-cytochrome species inhibition were investigated for this In the experiment, AbiAc and a sample of PSMA-Abi conjugate that specifically binds to PSMA were used . . .

     

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