Dapagliflozin prevents high-glucose-induced cellular senescence in renal tubular epithelial cells

HIGHLIGHTS

• who: Theodoros Eleftheriadis et al. from the Department of Nephrology, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, Larissa, Greece have published the paper: Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells, in the Journal: (JOURNAL) of 17/Dec/2022
• what: The authors evaluated the clinically relevant question of whether the already-in-clinical-use SGLT-2 inhibitor dapagliflozin prevents cell senescence in RPTECs exposed to high-glucose concentrations.
• how: In the experiments the authors used the therapeutic concentration of 15 ng/mL since 90% of the total . . .
  

   

  

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