Type i interferon signaling controls gammaherpesvirus latency in vivo

HIGHLIGHTS

• who: Johannes Schwerk et al. from the , Braunschweig, Germany Institute for Medical Microbiology, Otto von Guericke University Magdeburg, Magdeburg, Germany have published the Article: Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo, in the Journal: Pathogens 2022, 11, 1554. of /2022/
• what: The authors show that IFN expression and downstream signaling are induced in_vivo during acute MHV-68 infection, as well as upon reactivation from latency. Using this approach, the authors were able to show that MHV-68 reactivation and subsequent dissemination occur at a significantly higher rate in an Ifnar1-/- environment.
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