4‐o‐substituted glucuronic cyclophellitols are selective mechanism‐based heparanase inhibitors

HIGHLIGHTS

• who: -O-Substituted Glucuronic Cyclophellitols are and collaborators from the Leiden University Gorlaeus Laboratories, Einsteinweg, CC Leiden, The Netherlands have published the paper: 4u2010Ou2010Substituted Glucuronic Cyclophellitols are Selective Mechanismu2010Based Heparanase Inhibitors, in the Journal: (JOURNAL)
• what: The authors report on the discovery of glucurono-configured cyclitol derivatives featuring simple substituents at the 4-O-position as irreversible HPSE The authors show that these compounds unlike glucurono-cyclophellitol for HPSE over u03b2-D-exo-glucuronidase (GUSB) also in platelet lysate. The authors further explore the viability of substituted glucuronic cyclophellitols as selective HPSE inhibitors. The authors . . .
  

   

  

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