HIGHLIGHTS
- who: S. M. Zahid Hosen and colleagues from the Medical University, Russia have published the paper: Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU), in the Journal: (JOURNAL)
- what: In the orthotopic tumours in this model, the authors found that while vimentin expression was unchanged, E-cadherin expression was significantly elevated in U10-treated mice compared to the other groups in Figures 14D-F, suggesting inhibition of cancer cell EMT by PLAU inhibition. As outlined above, this study has clearly established that dysregulated PLAU and . . .
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