HIGHLIGHTS
SUMMARY
Galinsky et_al developed the COIL approach to estimate MOI from a panel of bi-allelic SNP data, but this method relies on monoclonal infections (MOI=1) for estimation of allele frequencies or requires external allele frequency data. The authors evaluated two recently developed MOI estimation approaches by simulating malaria transmission using an extended ABM, and sampling, estimating, and comparing MOI under three different transmission settings (i.e., "low", "moderate", or "high"). Interestingly, while most hosts with MOI and amp;lt; 3 show accurate MOI estimates, some can differ from the true MOI by up . . .
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