HIGHLIGHTS
- who: Yigan Zhang from the (UNIVERSITY) have published the article: ADAR1: a mast regulator of aging and immunity, in the Journal: (JOURNAL) of July/20,/2022
SUMMARY
Mediated programmed necrosis of cells and tumor immune activation. Conversely, targeted inhibition of ADAR1 can improve the activity of ZBP1 and activate RIPK3-MLKL-dependent programmed necrosis to enhance the efficacy of tumor immunotherapy. In terms of clinical transformation, since the structure of Z-RNA and Z-DNA are very similar, Z-DNA can also interact with the Zα domain of ZBP1 to activate ZBP1. Zhang . . .
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