HIGHLIGHTS
SUMMARY
Low-grade gliomas (LGG) are gliomas of low malignancy, and even though the prognosis is better than that of glioblastoma, many LGG progress to high-grade gliomas due to the great heterogeneity between different LGG, and thus the prognosis of LGG patients is poor. The development of LGG is closely related to immunity, and LGG cells can secrete a large number of cytokines that promote the entry of various immune cells into the tumor, which in turn creates a tumor microenvironment. The tumor microenvironment is involved in LGG growth, recurrence, invasion, and response to . . .
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