Extracellular cirp dysregulates macrophage bacterial phagocytosis in sepsis

HIGHLIGHTS

• who: Mian Zhou from the Experimental animals and sepsis induction Male C BL/, mice were purchased from Charles River Laboratories (Fairfield, NJ)CIRP-/- mice on the C BL/, background were provided by Dr. Jun Fujita (Kyoto University, Kyoto, Japan) as a kind gift [16]. Agematched, healthy male mice (9, weeks old) were used in all experiments. Sex-specific outcomes in rodent models of sepsis have been reported, and these differences result from male and female sex steroids performing diverse immunomodulatory functions [17]. Therefore, we used only male mice in this study to obtain consistent data. Animals were . . .
  

   

  

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