Targeting hur-vav3 mrna interaction prevents pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium

HIGHLIGHTS

• who: Mehdi Badaoui et al. from the Department of Cell Physiology and Metabolism, Faculty of medicine, University of have published the paper: Targeting HuR-Vav3 mRNA interaction prevents Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium, in the Journal: (JOURNAL)
• what: The authors report that Vav3 overexpression in CF is caused by upregulation of the mRNA-stabilizing protein HuR. By combining bioinformatic analysis and ribonucleoprotein immunoprecipitation, the authors demonstrate that HuR interacts physically with Vav3 mRNA. The authors show by confocal microscopy that targeting Vav3 mRNA stability by HuR inhibition markedly reduced apical fibronectin . . .
  

   

  

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