Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to dna damage

HIGHLIGHTS

  • who: Enrica Boda from the University of Turin, Turin, Italy have published the article: Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • what: The authors propose that cellautonomous mechanisms associated with OPC developmental origin underlie Cit-k KO dOPC vs. vOPC alternative fates in response to the same primary insult (i.e., equivalent accumulation of DNA damage).
  • how: To shed light on OPC heterogeneity here the authors analyzed a mouse model of microcephaly where . . .

     

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