Thiopurines impair the apical plasma membrane expression of cftr in pancreatic ductal cells via rac1 inhibition

HIGHLIGHTS

  • who: Bu00e1lint Tu00e9l from the Department of Pediatrics, Semmelweis University, Budapest have published the paper: Thiopurines impair the apical plasma membrane expression of CFTR in pancreatic ductal cells via RAC1 inhibition, in the Journal: (JOURNAL)
  • what: The authors report novel direct toxic effect of on pancreatic ductal cells suggest that the restoration of ductal function might help to prevent TIP in the future. The authors used different ex vivo and in_vivo model systems and explored the pathomechanism of TIP, which is one of the most common side effects of AZA treatment among IBD patients. The . . .

     

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