Ubiquilin-2 regulates pathological alpha-synuclein

HIGHLIGHTS

  • who: Stephanie S. Sandoval-Pistorius from the DepartmentUniversity of have published the paper: Ubiquilin-2 regulates pathological alpha-synuclein, in the Journal: Scientific Reports Scientific Reports
  • how: To further assess total u03b1-syn levels in_vivo | 13293 | 3 Vol.(0123456789) | Vol.(1234567890) 13293 | UBQLN2 targets pS129 u03b1u2011syn to the proteasome for degradation To test whether overexpression of UBQLN2 leads to an increased rate of u03b1-syn degradation the authors used optical pulse labeling to measure alpha-synuclein degradation over tu00ad ime34. For this experiment the authors used human u03b1-syn tagged with Dendra2 (hSyn-Dendra2) a . . .

     

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