HIGHLIGHTS
- who: Christabelle Rajesh and Prakash Radhakrishnan from the University of South Alabama, United States have published the research: The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers, in the Journal: (JOURNAL)
SUMMARY
The multitude of mechanisms that can lead to the presence of aberrantly glycosylated proteins and important events altered by these Tn and STn antigens to hijack tumor cell signaling in gastrointestinal cancers like pancreatic ductal adenocarcinoma (PDAC) and influence the infiltration of immune cells in the tumor niche are discussed in this review. Given the high expression of both these . . .
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