HIGHLIGHTS
- who: Posted Date June et al. from the (UNIVERSITY) have published the research: Aging reprogramming liver endothelial zonation triggers steatohepatitis by inactivating pericentral endothelium-derived C-kit, in the Journal: (JOURNAL)
- what: In current study, the authors demonstrated that aging inducing LSEC senescence disturbed sinusoid homeostasis in pericentral but not periportal ECs.
- how: Collectively these results indicated that C-kit deficiency-induced senescent LSECs underwent extensive gene profile alterations which potentially affected liver metabolism in an EC-mediated manner. Collectively these data indicated that endothelium-derived C-kit impeded LSEC-macrophage crosstalk by . . .
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